Endocrine Abstracts

Adrenal insufficiency can result in severe hyponatremia due to inappropriate high plasma vasopressin (pAVP). To elucidate the glucocorticoid AVP feedback we monitored thirsting of 12 male volunteers without and after on or five days of prednisolone (30 mg/d). Although prednisolone suppressed pAVP below 0.2 pg/ml the rise in plasma osmolality during thirsting was not influenced by prednisolone. Independent of exogenous glucocorticoid thirsting resulted in higher urine osmolalit...